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Products & Services

If you use a fluorescent or bioluminescent cell line now, you can easily switch to one of our cell lines to get the same results faster and easier.

Autobioluminescent Cells: Self-Generated & Self-Directed

Remove any error or variation resulting from human interaction.

We’ve engineered the autobioluminescent cells to produce a bioluminescent signal internally and without any investigator interaction, allowing them to signal continuously or to modulate that signal in response to changes in their environment or genetic expression patterns. Because the autobioluminescent signal is simply light, it can be assayed using the same equipment that you already use to monitor traditional bioluminescent cells, and can generally be interchanged freely with these cells within experimental designs.

Our cell lines are ideal for:

  • High throughput screening
  • Toxicity testing
  • Metabolic activity monitoring
  • Tumorigenesis and treatment studies
  • Estrogenic activity screening

Products & Services

Ready to use autobioluminescent cell lines let you order today and start assaying tomorrow.

These commonly used autobioluminescent cell lines integrate into existing assay protocols with minimal modifications so you can immediately take advantage of autobioluminescence. Simply substitute them in place of the traditional bioluminescent or fluorescent cell you’re using now and begin assaying without worrying about when to excite or monitor. Each cell continuously produces an autobioluminescent signal proportional to its metabolic activity level, providing unparalleled resolution on cellular response.

Your work is unique. Your solution should be too. You can’t change the world by doing the same thing as everyone else. For those who want to engineer inducible autobioluminescent expression, evaluate promoter function, or utilize unique cellular hosts, these vectors provide a platform to customize your assay system. For custom solutions without the work, contact us to discuss development of a custom cell line or vector DNA solution.

Autobioluminescent toxicity, estrogenicity, and androgenicity testing in a robust yeast-based system for industrial applications.

These yeast-based bioreporters use autobioluminescence to assay estrogenic and/or androgenic activity in environmental samples at speeds and sensitivities unmatched by current cell-based assays. This format is ideal for accessing the endocrine disruption potential of pesticides, plasticizers, synthetic hormones, and naturally occurring chemicals.

Specific autobioluminescent yeast strains for your unique application.

When you need to assay specifically for toxicity, estrogenicity, or androgenicity and need a robust, BSL1-level solution, an autobioluminescent yeast strain is your answer. These strains use the same autobioluminescent technology as our human cell lines, so you can be assured they will deliver the data you need without requiring human cell culture facilities.

490 BioTech is proud to serve as the industry’s premier provider of continuous, real-time, bioluminescent metabolic activity tracking assays. 

These assays, which continuously and non-invasively track the metabolic dynamics of relevant cell types over prolonged exposure periods to identify the metabolic and cytotoxic effects of compounds both pre- and post-metabolism, are ideally suited to rapidly and cost effectively position novel compound candidates for down-pipeline success. Contact us today to learn how our real-time bioluminescent monitoring approach can provide you with the pre-clinical development data you need to make more informed candidate selection decisions. Our approach provides an inexpensive alternative to in-house endpoint screens or costly out-sourcing alternatives so you can focus your time and resources on developing your next breakthrough candidate.

We are constantly engineering new autobioluminescent cell lines.

We can modify your existing cell lines or samples to express an autobioluminescent phenotype and return them to your laboratory for in-house testing at a fraction of the cost of purchasing and maintaining an existing, substrate-requiring cell line.

The autonomous bioluminescence of our cell lines provides you with…

  • Decreased costs
    There’s no need to purchase a separate luciferin
  • Increased imaging flexibility
    You can image on your own schedule
  • Easy integration into automated systems
    No treatment is required prior to light production
  • Image the same samples repeatedly
    No cellular destruction is required
  • Reduced hands-on time
    Simply plate and image–no additional steps required

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