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Autobioluminescence: Bioluminescence without luciferin

490 BioTech’s autobioluminescent technologies enable cells to autonomously control or continuously produce light without any external activation required. Choose from pre-made continuously luminescent human cell models, ready-to-use assay mixes that can make any cell glow for up to one week, robust, yeast-based environmental sensor kits, or custom solutions that allow you to get more information with less cost and effort than ever before.

Cardiomyocytes transected with 490 BioTech’s Ready-To-Use Autobioluminescent Toxicity Assay Mix continuously reporting changes in metabolic activity over a 40-hour period. The easily identified autobioluminescent signal reveals when effects occur, how long they last, and if they are permanent. Non-destructive autobioluminescence allows the 5 samples in this example to replace 12,000 samples using older luciferin-requiring bioluminescent technologies.

A New & Bright Idea

490 BioTech’s autobioluminescent technologies continuously report on biological events or interactions that affect metabolic status.

Incorporation of these technologies into cell culture and small animal preclinical efficacy/toxicity testing models accelerates the pace of new drug discovery and moves drugs more rapidly and effectively towards Phase I human testing with a reduced overall cost.

in vitro Imaging

Autobioluminescence is ideal for high throughput applications where using luciferin-requiring reporters would be cost prohibitive or where sample destruction would prevent repetitive data acquisition.

in vivo Imaging

Keep your animals and your IACUC happy. Switch to continuously bioluminescent cells to perform small animal studies without the repeated needle sticks required by luciferin induced systems.

Our Products

490 BioTech is proud to provide contract metabolic activity/toxicity services using our proprietary autobioluminescent technology. 

Our autobioluminescent human tissue models continuously and non-invasively track metabolic dynamics over prolonged exposure periods to identify both pre- and post-metabolism compound effects. Contact us today to learn how we can put autobioluminescent monitoring to work for you.


Custom Cell Lines

Do you have a specialty or proprietary tissue that can benefit from autobioluminescent expression?

We can modify your existing cell lines to produce data continuously without costly and potentially influential substrate addition or sample destruction. We can quickly modify your samples to express an autobioluminescent phenotype and return them to your laboratory for in-house testing at a fraction of the cost of purchasing and maintaining an existing, substrate-requiring cell line.


The 490 BioTech Difference

Our revolutionary new approach to optical imaging provides you with increased data acquisition in both tissues and small animal models. By taking advantage of our continuously light producing human cell lines it has finally become possible to break free from the expensive and error prone introduction of substrate.

Get back to doing what you do best – getting data.