490 BioTech

Welcome to 490 BioTech

490 BioTech is the only company that offers substrate-free bioluminescent human cell lines capable of continuously and autonomously producing light. This revolutionary new approach to optical imaging provides you with increased data acquisition in both tissues and small animal models. By taking advantage of our continuously light producing human cell lines it has finally become possible to break free from the expensive and error prone introduction of substrate and get back to doing what you do best – getting data.

in vitro Imaging

490 BioTech’s continuously bioluminescent cells are perfect for high throughput applications where the use of a luciferin requiring cell line would be cost prohibitive or where sample destruction would prevent repetitive data acquisition. Shown here in a 384 well format, our cells can be used across a wide variety of assay designs to suit your unique needs.

in vivo Imaging

Keep your animals and your IACUC happy by switching to continuously bioluminescent cells. The bioluminescence from 490 BioTech’s cell lines can be imaged through tissue, allowing you to perform small animal studies without the repeated needle sticks required from luciferin induced systems.

Technology assessment by the National Institutes of Health, National Center for Advancing Translational Sciences (NIH NCATS)

Head-to-head comparisons of 490 BioTech’s autobioluminescent cell lines versus conventional cell viability and proliferation assays under high-throughput screening formats. Published in The Journal of Laboratory Automation.

Read the report here.

The Scientist Top 10 Award

490 BioTech would like to thank The Scientist Magazine for recognizing our humanized bacterial luciferase as a Top 10 Innovation.

Visit The Scientist for more information.

NC3Rs Recognition

490 BioTech is honored to be recognized by the National Centre for the Replacement, Refinement, & Reduction of Animals in Research (NC3Rs) as a novel technology for reducing animal use and improving animal welfare. Visit the NC3Rs blog for more information.

Join the substrate free revolution!

We have an ever growing consortium of scientists and engineers using our cell lines to advance their innovative R&D objectives. Please contact us if we can assist you in achieving your research goals.

St. Jude Children’s Research Hospital
The National Institutes of Health
The Ohio State University
Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés (LISBP), France
University of New Haven
Momenta Pharmaceuticals
The Koch Institute for Integrative Cancer Research, MIT
John B. Pierce Laboratory, Yale University
Aalborg University, Denmark

Johns Hopkins University Medical School
The Rockefeller University
Oak Ridge National Laboratory
The University of Tennessee
Beth Israel Deaconess Medical Center
Massachusetts General Hospital
Riken Center for Developmental Biology, Japan
University of Ouro Preto, Brazil
Kiyatec, Inc.
University College, London